EFFICACY OF GUSELKUMAB, A SELECTIVE IL-23 INHIBITOR, IN PREVENTING ARTHRITIS IN A MULTICENTRE PSORIASIS AT-RISK COHORT (PAMPA): PROTOCOL OF A RANDOMISED, DOUBLE-BLIND, PLACEBO CONTROLLED MULTICENTRE TRIAL

Introduction Psoriatic arthritis (PsA) is a complex, immune-mediated disease associated with skin psoriasis that, if left untreated, can lead to joint destruction.Up to 30% of patients with psoriasis progress to PsA.In most cases, psoriasis precedes synovio-entheseal inflammation by an average of 5–7 years, providing a unique opportunity for earl

Research has shown that face-to-face victimization is a risk factor for the online victimization of adolescents, but no prior study has examined and compared four forms of face-to-face victimization (physical victimization, verbal victimization, social manipulation, and attacks on property) as significant correlates of general online victimization

Influenza is an acute respiratory infectious disease marked by its high contagiousness and rapid spread, caused by influenza viruses.Accurate influenza prediction is a critical issue in public health and serves as an essential tool for epidemiological studies.This paper seeks to improve the prediction accuracy of influenza-like illness (ILI) propor

Sustainability science encompasses a unique field that is defined through its purpose, the problem it Butter dish "Spread The love" addresses, and its solution-oriented agenda.However, this orientation creates significant methodological challenges.In this discussion paper, we conceptualize sustainability problems as wicked problems to tease out the